By Cary Dicken, Marie Menke, Genevieve Neal-Perry (auth.), Nanette F. Santoro, Genevieve Neal-Perry (eds.)
Amenorrhea: A Case-Based scientific advisor is a finished evaluation of the present wisdom relating to basic woman reproductive body structure. Replete with attention-grabbing case vignettes and offering diagnostic algorithms and healing techniques for amenorrhea, Amenorrhea: A Case-Based scientific consultant is split into 3 sections. the 1st part consists of 2 chapters that offer a radical assessment of easy technology and medical wisdom concerning the organ structures chargeable for basic body structure of the menstrual cycle. the second one part comprises dialogue approximately menstrual cycle disruption because it pertains to hypothalamic-pituitary disorder, surgical and usual menopause, genetic defects, untimely ovarian failure/insufficiency and the results of caloric extra and restrict. The 3rd part bargains an replace at the physiological results of lengthy amenorrhea brought about surgically or via hypothalamic disorder and likewise contains an unique bankruptcy that focuses completely at the impression of race and ethnicity at the occurrence and analysis of amenorrhea. Amenorrhea: A Case-Based scientific advisor brings jointly chapters from popular specialists who supply cutting-edge, clinically helpful info in a case-based, reader-friendly style. This name could be a great addition to the bookshelves of all clinicians who perform in women’s health and wellbeing settings.
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Extra info for Amenorrhea: A Case-Based, Clinical Guide
Ferrara N, Henzel WJ (1989) Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Esch F, Ueno N, Baird A (1985) Primary structure of bovine brain acidic fibroblast growth factor (FGF). Biochem Biophys Res Commun 133:554–562 47. Kech PJ, Hauser SD, Krivi G et al (1989) Vascular permeability factor, an endothelial cell mitogen related to platelet-derived growth factor. Science 246:1309–1312 48. Leung DW, Cachianes G, Kuang WJ et al (1989) Vascular endothelial growth factor is a secreted angiogenic mitogens.
Only the functionalis layer of endometrium is shed with each cycle. The basalis layer contains the progenitor cells that regenerate the functionalis layer in each cycle. Endometrial tissue responds to sex steroid hormones produced in the follicular and luteal phases of the ovarian cycle. The menstrual cycle is divided into proliferative and secretory phases, and cytoarchitectural and molecular differences between the phases reflect endometrial responses to cyclic changes in ovarian hormone exposure.
EGF may mediate the proliferative effects on epithelial cells seen in the endometrium during the early follicular phase when estradiol levels are generally very low. Transforming growth factor alpha (TGFa), a member of the EGF family, binds the same receptor as EGF and achieves peak levels during the mid-cycle. TGFa is also thought to mediate the proliferative actions of estrogen on the endometrium. Fibroblast growth factors (FGF) comprise a family of approximately nine members and of these, FGF-1, -2, -4, and -7 are expressed in human endometrium.
Amenorrhea: A Case-Based, Clinical Guide by Cary Dicken, Marie Menke, Genevieve Neal-Perry (auth.), Nanette F. Santoro, Genevieve Neal-Perry (eds.)